BDBM225230 EED226::US11013745, Compound EED226

SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12

InChI Key InChIKey=DYIRSNMPIZZNBK-UHFFFAOYSA-N

Data  88 IC50  4 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 225230   

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  23.4nMpH: 8.0Assay Description:To assess the compounds potency in the H3K27me0 peptide (21–44)-based PRC2 enzymatic assay, compounds were serially diluted three-fold in DMSO t...More data for this Ligand-Target Pair
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  53.5nMpH: 8.0Assay Description:To assess the compounds potency in the H3K27me0 peptide (21–44)-based PRC2 enzymatic assay, compounds were serially diluted three-fold in DMSO t...More data for this Ligand-Target Pair
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  20nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair